Synthesis of lipid membranes for artificial cells

KA Podolsky, NK Devaraj - Nature Reviews Chemistry, 2021 - nature.com
A major goal of synthetic biology is to understand the transition between non-living matter
and life. The bottom-up development of an artificial cell would provide a minimal system with …

Biomimicry of Cellular Motility and Communication Based on Synthetic Soft‐Architectures

L Wang, S Song, J van Hest, LKEA Abdelmohsen… - Small, 2020 - Wiley Online Library
Cells, sophisticated membrane‐bound units that contain the fundamental molecules of life,
provide a precious library for inspiration and motivation for both society and academia …

Phospholipid synthesis inside phospholipid membrane vesicles

S Eto, R Matsumura, Y Shimane, M Fujimi… - Communications …, 2022 - nature.com
Construction of living artificial cells from genes and molecules can expand our
understanding of life system and establish a new aspect of bioengineering. However, growth …

Chromatophores efficiently promote light-driven ATP synthesis and DNA transcription inside hybrid multicompartment artificial cells

E Altamura, P Albanese, R Marotta… - Proceedings of the …, 2021 - National Acad Sciences
The construction of energetically autonomous artificial protocells is one of the most
ambitious goals in bottom-up synthetic biology. Here, we show an efficient manner to build …

Membranization of coacervates into artificial phagocytes with predation toward bacteria

C Zhao, J Li, S Wang, Z Xu, X Wang, X Liu, L Wang… - ACS …, 2021 - ACS Publications
Coacervate-based membraneless organelles with diverse functionality as well as the
capability of mimicking intracellular physiological environments are attracting researchers' …

Stimuli-responsive vesicles as distributed artificial organelles for bacterial activation

I Gispert, JW Hindley, CP Pilkington… - Proceedings of the …, 2022 - National Acad Sciences
Intercellular communication is a hallmark of living systems. As such, engineering artificial
cells that possess this behavior has been at the heart of activities in bottom-up synthetic …

Connecting primitive phase separation to biotechnology, synthetic biology, and engineering

TZ Jia, PH Wang, T Niwa, I Mamajanov - Journal of biosciences, 2021 - Springer
One aspect of the study of the origins of life focuses on how primitive chemistries assembled
into the first cells on Earth and how these primitive cells evolved into modern cells …

Chemoadaptive polymeric assemblies by integrated chemical feedback in self-assembled synthetic protocells

S Pearce, J Perez-Mercader - ACS Central Science, 2021 - ACS Publications
The design and chemical synthesis of artificial material objects which can mimic the
functions of living cells is an important ongoing scientific endeavor. A key challenge …

Coupled metabolic cycles allow out‐of‐equilibrium autopoietic vesicle replication

AHJ Engwerda, J Southworth… - Angewandte Chemie …, 2020 - Wiley Online Library
We report chemically fuelled out‐of‐equilibrium self‐replicating vesicles based on surfactant
formation. We studied the vesicles' autocatalytic formation using UPLC to determine …

Emerging advances of cell‐free systems toward artificial cells

Y Zhu, X Guo, J Liu, F Li, D Yang - Small Methods, 2020 - Wiley Online Library
Artificial cells that mimic the architectural and functional characteristics of living cells not only
shed light on the physical principle of life but also facilitate development in the areas such as …