Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

A promising strategy to delay and perhaps prevent Alzheimer's disease (AD) is to identify the
age-related changes that put the brain at risk for the disease. A significant normal age …

Functional androgen receptor (AR) signaling is necessary for the development of prostate
cancer. The therapeutic effect of androgen deprivation therapy for prostate cancer was …

Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone introduced for
therapeutic purposes providing enhanced anabolic potency with reduced androgenic …

The neural basis of how learned vocalizations change during development and in adulthood
represents a major challenge facing cognitive neuroscience. This plasticity in the degree to …

We report here the design, preparation, and systematic evaluation of a novel cycloalkane [d]
isoxazole pharmacophoric fragment-containing androgen receptor (AR) modulators …

Objective: The extent to which aromatization of testosterone (T) to estradiol is required for
the observed effects of testosterone therapy on sexual function and well-being are not …

Selective androgen receptor modulators (SARM) are a prominent group of compounds for
being misused in sports owing to their advantageous anabolic properties and reduced side …

Androgen receptor (AR) signaling is necessary for the development of prostate cancer.
Androgen-deprivation therapy (ADT) for prostate cancer was described over 50 years ago …

Androgens can exert profound effects on the organization, development, and function of the
nervous system through activation of androgen receptors (ARs). Nonsteroidal and steroidal …