Accumulating clinical evidence indicates extensive inter-individual variations in the
effectiveness and adverse effects of standard treatment protocols, which are largely …

Most drugs are metabolized in the liver by cytochromes P450 (CYPs). Stress can modify
CYP-catalyzed drug metabolism and subsequently, the pharmacokinetic profile of a drug …

Volatile organic compounds (VOCs) are a group of pollutants pervasive in daily life with
identified adverse health effects. However, no study has investigated the variability in VOC …

The role of ethanol-inducible cytochrome P450-2E1 (CYP2E1) in promoting aging-
dependent hepatic disease is unknown and thus was investigated in this study. Young (7 …

Tamoxifen (TAM) is commonly used for cell type specific Cre recombinase-induced gene
inactivation and in cell fate tracing studies. Inducing a gene knockout by TAM and using non …

Angiomyofibroblastoma and superficial myofibroblastoma are distinctive benign
mesenchymal tumors occurring in the female lower genital tract. Despite their significant …

Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that
can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with …

Introduction: The available evidence suggests that psychophysiological stress regulates a
substantial number of factors, which in turn, can alter the pharmacokinetic parameters of a …

Abstract Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) is a top selling
analgesic used in more than 600 prescription and non-prescription pharmaceuticals. To …

Accumulating clinical evidence suggests significant inter-individual variations in the efficacy
of standard treatment protocols followed for several diseases, such as diabetes …