Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective …

Claudins are tight junction membrane proteins that are expressed in epithelia and
endothelia and form paracellular barriers and pores that determine tight junction …

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …

Throughout the biological world, a 30 Å hydrophobic film typically delimits the environments
that serve as the margin between life and death for individual cells. Biochemical and …

BACKGROUND: Asthma is a complex disease involving gene and environment interactions.
Although atopy is a strong predisposing risk factor for asthma, local tissue susceptibilities …

Tight junctions are one mode of cell–cell adhesion in epithelial and endothelial cellular
sheets. They act as a primary barrier to the diffusion of solutes through the intercellular …

Tight junctions (TJs) establish the epithelial barrier and are thought to form a membrane
fence to regulate epithelial polarity, although the roles of TJs in epithelial polarity remain …

Recombinant v-and t-SNARE proteins reconstituted into separate lipid bilayer vesicles
assemble into SNAREpins—SNARE complexes linking two membranes. This leads to …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …