Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances

H Jiang, X Wang - Biotechnology Advances, 2023 - Elsevier
Terpenoids are a large class of plant-derived compounds, that constitute the main
components of essential oils and are widely used as natural flavors and fragrances. The …

In-depth analysis of biocatalysts by microfluidics: An emerging source of data for machine learning

M Vasina, D Kovar, J Damborsky, Y Ding, T Yang… - Biotechnology …, 2023 - Elsevier
Nowadays, the vastly increasing demand for novel biotechnological products is supported
by the continuous development of biocatalytic applications which provide sustainable green …

Engineering Escherichia coli for production of geraniol by systematic synthetic biology approaches and laboratory-evolved fusion tags

X Wang, J Chen, J Zhang, Y Zhou, Y Zhang… - Metabolic …, 2021 - Elsevier
Geraniol is a valuable monoterpene extensively used in the fragrance, food, and cosmetic
industries. Increasing environmental concerns and supply gaps have motivated efforts to …

Synthesis of bioengineered heparin by recombinant yeast Pichia pastoris

Y Zhang, Y Wang, Z Zhou, P Wang, X Xi, S Hu… - Green …, 2022 - pubs.rsc.org
Heparin, the most widely used anticoagulant drug, is mainly acquired from livestock.
Variable structures and contaminations of other glycosaminoglycans of animal-sourced …

[HTML][HTML] Fungal cell factories for efficient and sustainable production of proteins and peptides

M Lübeck, PS Lübeck - Microorganisms, 2022 - mdpi.com
Filamentous fungi are a large and diverse taxonomically group of microorganisms found in
all habitats worldwide. They grow as a network of cells called hyphae. Since filamentous …

Cell Catalysis of Citrate to Itaconate by Engineered Halomonas bluephagenesis

J Zhang, B Jin, K Hong, Y Lv, Z Wang… - ACS Synthetic …, 2021 - ACS Publications
Itaconic acid (IA), an important five-carbon unsaturated dicarboxylic acid, is one of the top 12
renewable chemicals with an urgent need to reduce industrial production costs. Halomonas …

[HTML][HTML] The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production

D Wu, L Fu, W Wen, N Dong - Journal of Animal Science and …, 2022 - Springer
Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial
activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that …

[HTML][HTML] Improving protein quantity and quality—The next level of plant molecular farming

H Liu, MP Timko - International Journal of Molecular Sciences, 2022 - mdpi.com
Plants offer several unique advantages in the production of recombinant pharmaceuticals for
humans and animals. Although numerous recombinant proteins have been expressed in …

[PDF][PDF] The ongoing quest to crack the genetic code for protein production

T Nieuwkoop, M Finger-Bou, J van der Oost… - Molecular cell, 2020 - cell.com
Understanding the genetic design principles that determine protein production remains a
major challenge. Although the key principles of gene expression were discovered 50 years …