Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

Rhythms are a fundamental and defining feature of neuronal activity in animals including
humans. This rhythmic brain activity interacts in complex ways with rhythms in the internal …

Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces
Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral …

The glymphatic movement of fluid through the brain removes metabolic waste,,–.
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …

Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with
mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that …

Epidemiological studies identify midlife hearing loss as an independent risk factor for
dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this …