Glycoconjugate vaccines against antimicrobial resistant pathogens
C Sorieul, M Dolce, MR Romano, J Codée… - Expert Review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
Current advances in structure–function relationships and dose-dependent effects of human milk oligosaccharides
J Wang, MS Chen, RS Wang, JQ Hu, S Liu… - Journal of Agricultural …, 2022 - ACS Publications
HMOs (human milk oligosaccharides) are the third most important nutrient in breast milk. As
complex glycans, HMOs play an important role in regulating neonatal intestinal immunity …
complex glycans, HMOs play an important role in regulating neonatal intestinal immunity …
Glycovaccinology: The design and engineering of carbohydrate-based vaccine components
Vaccines remain one of the most important pillars in preventative medicine, providing
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …
Engineering the enzyme toolbox to tailor glycosylation in small molecule natural products and protein biologics
S Ouadhi, DMV López, FI Mohideen… - … , Design and Selection, 2023 - academic.oup.com
Many glycosylated small molecule natural products and glycoprotein biologics are important
in a broad range of therapeutic and industrial applications. The sugar moieties that decorate …
in a broad range of therapeutic and industrial applications. The sugar moieties that decorate …
Unlocking the power of sugar: carbohydrate ligands as key players in nanotherapeutic-assisted targeted cancer therapy
R Swami, S Vij, S Sharma - Nanomedicine, 2024 - Taylor & Francis
Cancer cells need as much as 40-times more sugar than their normal cell counterparts. This
sugar demand is attained by the excessive expression of inimitable transporters on the …
sugar demand is attained by the excessive expression of inimitable transporters on the …
Impact of glycosylation on viral vaccines
A Lembo, A Molinaro, C De Castro, F Berti… - Carbohydrate …, 2024 - Elsevier
Glycosylation is the most prominent modification important for vaccines and its specific
pattern depends on several factors that need to be considered when developing a new …
pattern depends on several factors that need to be considered when developing a new …
Reinvestigation of the internal glycan rearrangement of Lewis a and blood group type H1 epitopes
Protonated ions of fucose-containing oligosaccharides are prone to undergo internal glycan
rearrangement which results in chimeric fragments that obfuscate mass-spectrometric …
rearrangement which results in chimeric fragments that obfuscate mass-spectrometric …
[HTML][HTML] Impact and control of sugar size in glycoconjugate vaccines
G Stefanetti, CA MacLennan, F Micoli - Molecules, 2022 - mdpi.com
Glycoconjugate vaccines have contributed enormously to reducing and controlling
encapsulated bacterial infections for over thirty years. Glycoconjugate vaccines are based …
encapsulated bacterial infections for over thirty years. Glycoconjugate vaccines are based …
Multicomponent reaction derived small di-and tri-carbohydrate-based glycomimetics as tools for probing lectin specificity
Lectins, carbohydrate-binding proteins, play important functions in all forms of life from
bacteria and viruses to plants, animals, and humans, participating in cell–cell …
bacteria and viruses to plants, animals, and humans, participating in cell–cell …
Mass spectrometry-based shotgun glycomics for discovery of natural ligands of glycan-binding proteins
The non-covalent associations of complex carbohydrates (glycans) with glycan-binding
proteins mediate many important physiological and pathophysiological processes …
proteins mediate many important physiological and pathophysiological processes …