Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the
isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional …

Background—Heart failure with preserved left ventricular (LV) ejection fraction (EF) is
increasingly recognized and usually referred to as diastolic heart failure (DHF). Its …

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the
giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend …

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …

The 364 exon TTN gene encodes titin (TTN), the largest known protein, which plays key
structural, developmental, mechanical, and regulatory roles in cardiac and skeletal muscles …

The sarcomeric titin springs influence myocardial distensibility and passive stiffness. Titin-
isoform composition and protein kinase-A-dependent titin phosphorylation are variables …

High diastolic stiffness of failing myocardium results from interstitial fibrosis and elevated
resting tension (F passive) of cardiomyocytes. A shift in titin isoform expression from N2BA to …

Abnormalities of diastolic function are common to virtually all forms of cardiac failure.
However, their underlying mechanisms, precise role in the generation and phenotypic …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and
heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent …

Aims Heart failure (HF) with preserved ejection fraction (HFpEF) is a major cause of
morbidity and mortality. Key alterations in HFpEF include increased left ventricular (LV) …