Drug resistance (DR) is the major limiting factor in the successful treatment of systemic
neoplasia with cytotoxic chemotherapy. DR can be either intrinsic or acquired, and although …

Several classes of chemotherapy drugs are used as first line or adjuvant treatment of the
majority of tumour types in veterinary oncology. However, some types of tumour are …

Background: Alkylphospholipids (APLs) are synthetically derived from cell membrane
components, which they target and thus modify cellular signalling and cause diverse effects …

The standard of care treatment for canine lymphoma is multi‐agent chemotherapy
containing prednisolone, cyclophosphamide, vincristine and an anthracycline such as …

Orally administered daily chemotherapy offers a novel treatment approach for canine
lymphoma in a population of dogs that have failed or not tolerated maximum tolerable dose …

The most important causes of treatment failure in canine lymphoma include intrinsic or
acquired drug resistance. Thus, elucidation of molecular mechanisms of drug resistance is …

Abnormal DNA methylation is involved in the initiation and progression of lymphoid tumors.
Hence, DNA demethylating agents are promising candidate drugs for chemotherapy against …

Background Leukemia/lymphoma cell lines have been critical in the investigation of the
pathogenesis and therapy of hematological malignancies. While human LL cell lines have …