Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

The parasites Leishmania spp., Trypanosoma brucei, and Trypanosoma cruzi are the
trypanosomatid protozoa that cause the deadly human diseases leishmaniasis, African …

Unusually for a eukaryote, genes transcribed by RNA polymerase II (pol II) in Trypanosoma
brucei are arranged in polycistronic transcription units. With one exception, no pol II …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

To evade the host immune system, several pathogens periodically change their cell-surface
epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating …

Current therapies for human parasite infections rely on a few drugs, most of which have
severe side effects, and their helpfulness is being seriously compromised by the drug …

Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs)
to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are …

Histone post-translational modifications (PTMs) comprise one of the most intricate nuclear
signaling networks that govern gene expression in a long-term and dynamic fashion. These …

A unifying feature of eukaryotic nuclear organization is genome segregation into
transcriptionally active euchromatin and transcriptionally repressed heterochromatin. In …

Epigenetic regulation is important in many facets of eukaryotic biology. Recent work has
suggested that the basic mechanisms underlying epigenetic regulation extend to eukaryotic …