The role of integration and clonal expansion in HIV infection: live long and prosper
EM Anderson, F Maldarelli - Retrovirology, 2018 - Springer
Integration of viral DNA into the host genome is a central event in the replication cycle and
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …
Insight into treatment of HIV infection from viral dynamics models
The odds of living a long and healthy life with HIV infection have dramatically improved with
the advent of combination antiretroviral therapy. Along with the early development and …
the advent of combination antiretroviral therapy. Along with the early development and …
Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection
CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
[HTML][HTML] Dual TLR2 and TLR7 agonists as HIV latency-reversing agents
AB Macedo, CL Novis, CM De Assis, ES Sorensen… - JCI insight, 2018 - ncbi.nlm.nih.gov
The presence of a reservoir of latently infected cells in HIV-infected patients is a major
barrier towards finding a cure. One active cure strategy is to find latency-reversing agents …
barrier towards finding a cure. One active cure strategy is to find latency-reversing agents …
Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1
LN Bertagnolli, J Varriale, S Sweet… - Proceedings of the …, 2020 - National Acad Sciences
In untreated HIV-1 infection, rapid viral evolution allows escape from immune responses.
Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent …
Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent …
Apple AP2/EREBP transcription factor MdSHINE2 confers drought resistance by regulating wax biosynthesis
YL Zhang, CL Zhang, GL Wang, YX Wang, CH Qi… - Planta, 2019 - Springer
Main conclusion This study showed that AP2/EREBP transcription factor MdSHINE2
functioned in mediating cuticular permeability, sensitivity to abscisic acid (ABA), and drought …
functioned in mediating cuticular permeability, sensitivity to abscisic acid (ABA), and drought …
New frontiers in measuring and characterizing the HIV reservoir
SD Falcinelli, C Ceriani, DM Margolis… - Frontiers in …, 2019 - frontiersin.org
A cure for HIV infection remains elusive due to the persistence of replication-competent HIV
proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite …
proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite …
[HTML][HTML] HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy
EM Stevenson, AR Ward, R Truong, AS Thomas… - JCI insight, 2021 - ncbi.nlm.nih.gov
Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-
lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is …
lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is …
T-cell receptor repertoire sequencing and its applications: focus on infectious diseases and cancer
The immune system is a dynamic feature of each individual and a footprint of our unique
internal and external exposures. Indeed, the type and level of exposure to physical and …
internal and external exposures. Indeed, the type and level of exposure to physical and …
Transcriptional stochasticity as a key aspect of HIV-1 latency
A Damour, V Slaninova, O Radulescu, E Bertrand… - Viruses, 2023 - mdpi.com
This review summarizes current advances in the role of transcriptional stochasticity in HIV-1
latency, which were possible in a large part due to the development of single-cell …
latency, which were possible in a large part due to the development of single-cell …