Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Patients with non-small-cell lung cancer (NSCLC) whose tumours harbour activating
mutations within the epidermal growth factor receptor (EGFR) frequently derive significant …

Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-
acid-related diseases. However, in the past decade, a steadily increasing list of …

Drug interactions are of major concern, since cancer patients take many medications and
may have serious consequences. Therefore, a study was designed to identify interactions …

Glioblastoma (GBM) is increasingly recognized as a disease involving dysfunctional cellular
metabolism. GBMs are known to be complex heterogeneous systems containing multiple …

Purpose Erlotinib depends on stomach pH for its bioavailability. When erlotinib is taken
concurrently with a proton pump inhibitor (PPI), stomach pH increases, which results in a …

Background The concomitant use of tyrosine kinase inhibitors (TKIs) and proton pump
inhibitors (PPIs) is a significant concern because of potential drug‐drug interaction that …

Importance Capecitabine is an oral cytotoxic chemotherapeutic commonly used across
cancer subtypes. As with other oral medications though, it may suffer from drug interactions …

Purpose: Pazopanib is active in soft-tissue sarcoma (STS). Because pazopanib absorption
is pH-dependent, coadministration with gastric acid–suppressive (GAS) agents such as …

Interstitial acidification is a hallmark of solid tumor tissues resulting from the combination of
different factors, including cellular buffering systems, defective tissue perfusion and high …