Recent advances in emerging PCOS therapies

KA Glendining, RE Campbell - Current Opinion in Pharmacology, 2023 - Elsevier
Polycystic ovary syndrome is a prevalent endocrinopathy involving androgen excess, and
anovulatory infertility. The disorder is also associated with many comorbidities such as …

Kisspeptin neuron electrophysiology: Intrinsic properties, hormonal modulation, and regulation of homeostatic circuits

BB Jamieson, R Piet - Frontiers in Neuroendocrinology, 2022 - Elsevier
The obligatory role of kisspeptin (KISS1) and its receptor (KISS1R) in regulating the
hypothalamic-pituitary–gonadal axis, puberty and fertility was uncovered in 2003. In the few …

[HTML][HTML] Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors

M Ruiz-Cruz, C Torres-Granados… - Current Opinion in …, 2023 - Elsevier
Gonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain
control of reproduction. The activity of this neuronal population, mainly located at the …

[HTML][HTML] GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice

C Liu, WH Liu, W Yang, L Chen, Y Xue, XY Chen - Neuropharmacology, 2024 - Elsevier
The spontaneous firing activity of nigral dopaminergic neurons is associated with some
important roles including modulation of dopamine release, expression of tyrosine …

Cholinergic Control of GnRH Neuron Physiology and Luteinizing Hormone Secretion in Male Mice: Involvement of ACh/GABA Cotransmission

C Vastagh, I Farkas, V Csillag, M Watanabe… - Journal of …, 2024 - Soc Neuroscience
Gonadotropin-releasing hormone (GnRH)-synthesizing neurons orchestrate reproduction
centrally. Early studies have proposed the contribution of acetylcholine (ACh) to …

The GLP-1 agonist, exendin-4, stimulates LH secretion in female sheep

EM Simpson, IJ Clarke, CJ Scott… - Journal of …, 2023 - joe.bioscientifica.com
Our previous studies showed that microinjection into the median eminence of the sheep of
glucagon-like peptide-1 (GLP-1) or its receptor agonist exendin-4 stimulates luteinising …

Cholinergic control of GnRH neuron physiology and luteinizing hormone secretion: involvement of ACh/GABA co-transmission

C Vastagh, I Farkas, V Csillag, M Watanabe, I Kalló… - bioRxiv, 2023 - biorxiv.org
Abstract Gonadotropin-releasing hormone (GnRH)-synthesizing neurons orchestrate
reproduction centrally. Early studies have proposed the contribution of acetylcholine (ACh) …

胰高糖素样肽-1 受体激动剂改善肥胖致雄性生殖功能下降的作用机制

贾卓雅, 陈晓依, 陈树春 - 临床荟萃, 2022 - huicui.hebmu.edu.cn
肥胖可以通过诱发瘦素抵抗, 诱导炎症和氧化应激等多种机制影响中央和外周的下丘脑-垂体-
性腺轴, 导致雄性生殖功能下降, 包括精子发生改变, 精子数量减少, 精子DNA 凋亡增加 …

Sindrome dell'ovaio policistico: ruolo del glucagon-like peptide 1 (GLP-1) nella regolazione dell'asse ipotalamo-ipofisi-ovaio

G Pugliese, G de Alteriis, S Savastano - L'Endocrinologo, 2023 - Springer
L'obesità e l'insulino-resistenza associate alla sindrome dell'ovaio policistico (PCOS) hanno
stimolato studi clinici sull'efficacia degli agonisti recettoriali del Glucagon-like Peptide 1 …

Neuroanatomy of the GnRH/Kisspeptin System

DJ Spergel - Neuroanatomy of Neuroendocrine Systems, 2022 - Springer
This chapter summarizes the current body of knowledge regarding the neuroanatomy of the
gonadotropin-releasing hormone (GnRH)/kisspeptin system controlling fertility. It focuses on …