Despite recent advances in both surgery and chemoradiotherapy, mortality rates for
advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one …

As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer
efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for …

Abstract Purpose: Testing safety of Delta24-RGD (DNX-2401), an oncolytic adenovirus,
locally delivered by convection enhanced delivery (CED) in tumor and surrounding brain of …

Oncolytic virotherapy is a therapeutic approach that uses replication-competent viruses to
kill cancers. The ability of oncolytic viruses to selectively replicate in cancer cells leads to …

BACKGROUND/AIMS: We have investigated the role of natural killer (NK) cells in hepatic
fibrogenesis. Mouse NK cells express both inhibitory/activating-killing-immunoglobulin …

Enteric viruses are important pathogens found in contaminated surface waters and have
previously been detected in waters of the Great Lakes. Human adenoviruses were …

Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx,
oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide …

Targeted therapy of cancer using oncolytic viruses has generated much interest over the
past few years in the light of the limited efficacy and side effects of standard cancer …

Oncolytic viruses are novel anticancer agents, currently under investigation in Phase I–III
clinical trials. Until recently, most studies have focused on the direct antitumor properties of …

Oncolytic viruses capable of tumor-selective replication and cytolysis have shown early
promise as cancer therapeutics. However, the host immune system remains a significant …