[HTML][HTML] Inflammasome activation and regulation: toward a better understanding of complex mechanisms

D Zheng, T Liwinski, E Elinav - Cell discovery, 2020 - nature.com
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

[HTML][HTML] The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation

HA Saleh, MH Yousef, A Abdelnaser - Frontiers in immunology, 2021 - frontiersin.org
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

[HTML][HTML] Pre-and post-harvest factors affecting glucosinolate content in broccoli

R Ilahy, I Tlili, Z Pék, A Montefusco, MW Siddiqui… - Frontiers in …, 2020 - frontiersin.org
Owing to several presumed health-promoting biological activities, increased attention is
being given to natural plant chemicals, especially those frequently entering the human diet …

Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review

S Khan, KA Awan, MJ Iqbal - Journal of Food Biochemistry, 2022 - Wiley Online Library
Sulforaphane belongs to the active class of isothiocyanates capable of delivering various
biological benefits for health promotion and disease prevention. This compound is …

Inhibitory effects of sulforaphane on NLRP3 inflammasome activation

C Kiser, CP Gonul, M Olcum, S Genc - Molecular immunology, 2021 - Elsevier
SFN, a dietary phytochemical, is a significant member of isothiocyanates present in
cruciferous vegetables at high levels in broccoli. It is a well-known activator of the Nrf2/ARE …

Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease

LFMF Cardozo, LA Alvarenga, M Ribeiro, L Dai… - Nutrition …, 2021 - academic.oup.com
Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables
(Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 …

Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway

E Molaei, A Molaei, F Abedi, AW Hayes… - Food Science & …, 2021 - Wiley Online Library
Nephropathy can occur following exposure of the kidneys to oxidative stress. Oxidative
stress is the result of reactive oxygen species (ROS) formation due to intracellular …

[HTML][HTML] Preclinical investigations on broccoli-derived sulforaphane for the treatment of ophthalmic disease

FAA Kwa, BV Bui, BR Thompson, LN Ayton - Drug Discovery Today, 2023 - Elsevier
Vision loss causes a significant burden on individuals and communities on a financial,
emotional and social level. Common causes include age-related macular degeneration …

[HTML][HTML] Therapeutic implications of inflammasome in inflammatory bowel disease

V Khatri, R Kalyanasundaram - FASEB journal: official publication …, 2021 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) remains a persistent health problem with a global burden
surging over 6.8 million cases currently. Clinical pathology of IBD is complicated; however …

[HTML][HTML] Interplay between phytochemicals and the colonic microbiota

C Kwon, MK Ediriweera, S Kim Cho - Nutrients, 2023 - mdpi.com
Phytochemicals are natural compounds found in food ingredients with a variety of health-
promoting properties. Phytochemicals improve host health through their direct systematic …