Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Sirtuins in atherosclerosis: guardians of healthspan and therapeutic targets
MOJ Grootaert, MR Bennett - Nature Reviews Cardiology, 2022 - nature.com
Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …
[HTML][HTML] NAD+ Homeostasis and NAD+-Consuming Enzymes: Implications for Vascular Health
R Campagna, A Vignini - Antioxidants, 2023 - mdpi.com
Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …
Targeting SIRT1 rescues age-and obesity-induced microvascular dysfunction in ex vivo human vessels
Background: Experimental evidence suggests a key role of SIRT1 (silent information
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …
[HTML][HTML] Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury
R Campagna, Ł Mateuszuk, K Wojnar-Lason… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Nicotinamide N-methyltransferase (NNMT, EC 2.1. 1.1.) plays an important role in
the growth of many different tumours and is also involved in various non-neoplastic …
the growth of many different tumours and is also involved in various non-neoplastic …
[HTML][HTML] The role of Sirtuin1 in regulating endothelial function, arterial remodeling and vascular aging
Sirtuin1 (SIRT1), which belongs to a highly conserved family of protein deacetylase, is one
of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including …
of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including …
[HTML][HTML] Cellular and molecular biology of sirtuins in cardiovascular disease
Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …
Endothelial SIRT1 as a target for the prevention of arterial aging: promises and challenges
MK Begum, D Konja, S Singh… - Journal of …, 2021 - journals.lww.com
SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …
Conductance artery wall layers and their respective roles in the clearance functions
JB Michel, J Lagrange, V Regnault… - … , and vascular biology, 2022 - Am Heart Assoc
Evolutionary organization of the arterial wall into layers occurred concomitantly with the
emergence of a highly muscularized, pressurized arterial system that facilitates outward …
emergence of a highly muscularized, pressurized arterial system that facilitates outward …
Circadian biology and the neurovascular unit
Mammalian physiology and cellular function are subject to significant oscillations over the
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …