Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …

Background: Experimental evidence suggests a key role of SIRT1 (silent information
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …

Abstract Nicotinamide N-methyltransferase (NNMT, EC 2.1. 1.1.) plays an important role in
the growth of many different tumours and is also involved in various non-neoplastic …

Sirtuin1 (SIRT1), which belongs to a highly conserved family of protein deacetylase, is one
of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including …

Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …

SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …

Evolutionary organization of the arterial wall into layers occurred concomitantly with the
emergence of a highly muscularized, pressurized arterial system that facilitates outward …

Mammalian physiology and cellular function are subject to significant oscillations over the
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …