Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

Malignant transformation of cells depends on accumulation of DNA damage. Over the past
years we have learned that the T cell–based immune system frequently responds to the …

T cells are important for effective viral clearance, elimination of virus-infected cells, and long-
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …

Synthetic gene circuits that precisely control human cell function could expand the
capabilities of gene-and cell-based therapies. However, platforms for developing circuits in …

Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …

In the past two decades, 7 coronaviruses have infected the human population, with two
major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012 …

A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …

Defects in pathways governing genomic fidelity have been linked to improved response to
immune checkpoint blockade therapy (ICB). Pathogenic POLE/POLD1 mutations can cause …

The clinical relevance of T cells in the control of a diverse set of human cancers is now
beyond doubt. However, the nature of the antigens that allow the immune system to …

Abstract The Immune Epitope Database Analysis Resource (IEDB-AR, http://tools. iedb. org/)
is a companion website to the IEDB that provides computational tools focused on the …