During pregnancy, several tightly coordinated and regulated processes take place to enable
proper fetal development and gestational success. The formation and development of the …

BACKGROUND Initially identified as suppressors of metastasis in various types of cancer,
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …

Neurotrophins are a family of functionally and structurally related proteins which play a key
role in the survival, development, and function of neurons in both the central and peripheral …

The precise regulation of extravillous trophoblast invasion of the uterine wall is a key
process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell …

Purpose Kisspeptins regulate the trophoblast invasion. The disturbance of this process
might lead to the development of preeclampsia (PE). Diabetes mellitus (DM) is associated …

Kisspeptin (KISS1) is encoded by the KISS1 gene and was initially found to be a repressor
of metastasis. Natural mutations in the KISS1 receptor gene (KISS1R) were subsequently …

In utero co-exposure to endocrine disrupting compounds can perturb fetal development.
However, the effect of co-exposure on pivotal regulatory genes has seldom been …

Kisspeptin and its receptor are central to reproductive health acting as key regulators of the
reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator …

Gestational diseases such as preeclampsia and gestational diabetes cause inflammasome
activation and pyroptosis in the placenta and changes in placental kisspeptin levels …

Context Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal
growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated …