Telomeropathies are rare disorders associated with impaired telomere length control
mechanisms that frequently result from genetic mutations in the telomerase complex …

Nucleic acid-based systems play important roles in antiviral defense, including CRISPR/Cas
that adopts RNA-guided DNA cleavage to prevent DNA phage infection and RNA …

Embryonic stem cells (ESCs) and meiosis are featured by relatively higher frequent
homologous recombination associated with DNA double strand breaks (DSB) repair. Here …

Human perinatal stem cells (SCs) can be isolated from fetal annexes without ethical or
safety limitations. They are generally considered multipotent; nevertheless, their biological …

Functional telomeres protect chromosome ends and play important roles in stem cell
maintenance and differentiation. Short telomeres negatively impact germ cell development …

Background Telomeres consist of repetitive DNA sequences at the chromosome ends to
protect chromosomal stability, and primarily maintained by telomerase or occasionally by …

Mouse embryonic stem (ES) cell cultures exhibit heterogeneity and recently are discovered
to sporadically enter the 2-cell (2C)-embryo state, critical for ES potency. Zscan4 could mark …

The majority of cancer cells rely on elevated telomerase expression and activity for rapid
growth and proliferation. Telomerase-negative cancer cells, by contrast, often employ the …

Various culture conditions by small molecules have been explored to extend pluripotency of
stem cells, but their impacts on cell fate in vivo remain elusive. We systematically compared …

Telomerase is associated with cellular aging, and its presence limits cellular lifespan.
Telomerase by preventing telomere shortening can extend the number of cell divisions for …