Tcstv1 and Tcstv3 elongate telomeres of mouse ES cells
Mouse embryonic stem cell (ESC) cultures exhibit a heterogeneous mixture of metastable
cells sporadically entering the 2-cell (2C)-embryo-like state, critical for ESC potency. One of …
cells sporadically entering the 2-cell (2C)-embryo-like state, critical for ESC potency. One of …
KSR-based medium improves the generation of high-quality mouse iPS cells
Induced pluripotent stem (iPS) cells from somatic cells have great potential for regenerative
medicine. The efficiency in generation of iPS cells has been significantly improved in recent …
medicine. The efficiency in generation of iPS cells has been significantly improved in recent …
TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells
S Yin, F Zhang, S Lin, W Chen, K Weng, D Liu, C Wang… - Stem Cell Reports, 2022 - cell.com
Telomere integrity is critical for embryonic development, and core telomere-binding proteins,
such as TIN2, are key to maintaining telomere stability. Here, we report that homozygous …
such as TIN2, are key to maintaining telomere stability. Here, we report that homozygous …
Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity
FL Chan, B Vinod, K Novy, RB Schittenhelm… - Nucleic acids …, 2017 - academic.oup.com
Abstract AURKB (Aurora Kinase B) is a serine/threonine kinase better known for its role at
the mitotic kinetochore during chromosome segregation. Here, we demonstrate that AURKB …
the mitotic kinetochore during chromosome segregation. Here, we demonstrate that AURKB …
Properties of human embryonic stem cells and their differentiated derivatives depend on nonhistone DNA-binding HMGB1 and HMGB2 proteins
HMGB1 and HMGB2 proteins have been implicated in numerous cellular processes,
including proliferation, differentiation, apoptosis, and tumor growth. It is unknown whether …
including proliferation, differentiation, apoptosis, and tumor growth. It is unknown whether …
[PDF][PDF] Primitive stem cells in adult human peripheral blood
HE Young, F Lochner, D Lochner, D Lochner… - J Stem Cell …, 2017 - academia.edu
Recent reports demonstrated the presence of primitive endogenous stem cells circulating
within adult cat, dog, sheep, goat, pig, cow, and horse peripheral blood. The current study …
within adult cat, dog, sheep, goat, pig, cow, and horse peripheral blood. The current study …
Telomere reprogramming and maintenance in porcine iPS cells
Telomere reprogramming and silencing of exogenous genes have been demonstrated in
mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to …
mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to …
Efficient Induction of Pluripotent Stem Cells from Granulosa Cells by Oct4 and Sox2
Various types of somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells.
Somatic stem cells exhibit enhanced reprogramming efficiency by fewer factors, in contrast …
Somatic stem cells exhibit enhanced reprogramming efficiency by fewer factors, in contrast …
In medio stat virtus: unanticipated consequences of telomere dysequilibrium
L Harrington, F Pucci - … of the Royal Society B: Biological …, 2018 - royalsocietypublishing.org
The integrity of chromosome ends, or telomeres, depends on myriad processes that must
balance the need to compact and protect the telomeric, G-rich DNA from detection as a …
balance the need to compact and protect the telomeric, G-rich DNA from detection as a …
Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription
X Zhang, C Zhang, D Zhou, T Zhang, X Chen, J Ren… - Iscience, 2023 - cell.com
Zygotic genome activation (ZGA) is initiated once the genome chromatin state is organized
in the newly formed zygote. Telomeres are specialized chromatin structures at the ends of …
in the newly formed zygote. Telomeres are specialized chromatin structures at the ends of …