New insights into microglial mechanisms of memory impairment in Alzheimer's disease

N Li, M Deng, G Hu, N Li, H Yuan, Y Zhou - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common progressive and irreversible
neurodegeneration characterized by the impairment of memory and cognition. Despite years …

[HTML][HTML] Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants

A Nasir, OK Afridi, H Khan, Q Bai - Pharmacological Research, 2024 - Elsevier
Sciatica characterized by irritation, inflammation, and compression of the lower back nerve,
is considered one of the most common back ailments globally. Currently, the therapeutic …

The core of maintaining neuropathic pain: crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

T Zhang, M Zhang, S Cui, W Liang, Z Jia… - Brain and …, 2023 - Wiley Online Library
Background Neuropathic pain (NP) caused by the injury or dysfunction of the nervous
system is a chronic pain state accompanied by hyperalgesia, and the available clinical …

Utilizing machine learning to predict post-treatment outcomes in chronic non-specific neck pain patients undergoing cervical extension traction

IM Moustafa, DU Ozsahin, MT Mustapha, A Ahbouch… - Scientific Reports, 2024 - nature.com
This study explored the application of machine learning in predicting post-treatment
outcomes for chronic neck pain patients undergoing a multimodal program featuring cervical …

Analgesic effect of perineural injection of BoNT/A on neuropathic pain induced by chronic constriction injury of sciatic nerve in rats

J He, X Wei, M Wu, Z Song, L Jiang, W Zhang - Neurochemical Research, 2023 - Springer
This study was designed to investigate the analgesic effect of perineural injection of BoNT/A
on neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) and possible …

[HTML][HTML] Clemastine-induced enhancement of hippocampal myelination alleviates memory impairment in mice with chronic pain

T Zhu, H Wang, P Liu, H Gu, W Pan, M Zhao… - Neurobiology of …, 2024 - Elsevier
Patients with chronic pain often experience memory impairment, but the underlying
mechanisms remain elusive. The myelin sheath is crucial for rapid and accurate action …

A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice

I Martínez-Martel, O Pol - Antioxidants, 2023 - mdpi.com
Patients undergoing chemotherapy with cisplatin (CIS) develop neuropathy in addition to
other symptoms such as, anxiety, depression, muscle wasting and body weight loss. This …

Research progress in the mechanism of acupuncture regulating microglia in the treatment of Alzheimer's disease

J Liu, J Zhou, C You, H Xia, Y Gao, Y Liu… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disease in the central
nervous system, characterized by memory and cognitive dysfunction. Acupuncture is an …

Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway

S Han, X Yuan, F Zhao, A Manyande, F Gao… - Inflammation …, 2024 - Springer
Objective Cognitive dysfunction is a common comorbidity in patients with chronic pain.
Activation of Liver X receptors (LXRs) plays a potential role in improving cognitive disorders …

[HTML][HTML] Irisin alleviates chronic constriction injury-induced hyperalgesia and affective disorders in mice through NF-κB and Nrf2 signaling pathways

X Xie, X Yu, H Zhang, H Dai, Y Huang, F Wu - IBRO Neuroscience Reports, 2024 - Elsevier
This research is to explore the impacts of irisin on hyperalgesia and behavioral deficits
caused by chronic constriction injury (CCI) and the underlying mechanisms. The CCI mice …