New insights into microglial mechanisms of memory impairment in Alzheimer's disease
N Li, M Deng, G Hu, N Li, H Yuan, Y Zhou - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common progressive and irreversible
neurodegeneration characterized by the impairment of memory and cognition. Despite years …
neurodegeneration characterized by the impairment of memory and cognition. Despite years …
[HTML][HTML] Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants
Sciatica characterized by irritation, inflammation, and compression of the lower back nerve,
is considered one of the most common back ailments globally. Currently, the therapeutic …
is considered one of the most common back ailments globally. Currently, the therapeutic …
The core of maintaining neuropathic pain: crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)
T Zhang, M Zhang, S Cui, W Liang, Z Jia… - Brain and …, 2023 - Wiley Online Library
Background Neuropathic pain (NP) caused by the injury or dysfunction of the nervous
system is a chronic pain state accompanied by hyperalgesia, and the available clinical …
system is a chronic pain state accompanied by hyperalgesia, and the available clinical …
Utilizing machine learning to predict post-treatment outcomes in chronic non-specific neck pain patients undergoing cervical extension traction
This study explored the application of machine learning in predicting post-treatment
outcomes for chronic neck pain patients undergoing a multimodal program featuring cervical …
outcomes for chronic neck pain patients undergoing a multimodal program featuring cervical …
Analgesic effect of perineural injection of BoNT/A on neuropathic pain induced by chronic constriction injury of sciatic nerve in rats
J He, X Wei, M Wu, Z Song, L Jiang, W Zhang - Neurochemical Research, 2023 - Springer
This study was designed to investigate the analgesic effect of perineural injection of BoNT/A
on neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) and possible …
on neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) and possible …
[HTML][HTML] Clemastine-induced enhancement of hippocampal myelination alleviates memory impairment in mice with chronic pain
T Zhu, H Wang, P Liu, H Gu, W Pan, M Zhao… - Neurobiology of …, 2024 - Elsevier
Patients with chronic pain often experience memory impairment, but the underlying
mechanisms remain elusive. The myelin sheath is crucial for rapid and accurate action …
mechanisms remain elusive. The myelin sheath is crucial for rapid and accurate action …
A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice
I Martínez-Martel, O Pol - Antioxidants, 2023 - mdpi.com
Patients undergoing chemotherapy with cisplatin (CIS) develop neuropathy in addition to
other symptoms such as, anxiety, depression, muscle wasting and body weight loss. This …
other symptoms such as, anxiety, depression, muscle wasting and body weight loss. This …
Research progress in the mechanism of acupuncture regulating microglia in the treatment of Alzheimer's disease
J Liu, J Zhou, C You, H Xia, Y Gao, Y Liu… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disease in the central
nervous system, characterized by memory and cognitive dysfunction. Acupuncture is an …
nervous system, characterized by memory and cognitive dysfunction. Acupuncture is an …
Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway
S Han, X Yuan, F Zhao, A Manyande, F Gao… - Inflammation …, 2024 - Springer
Objective Cognitive dysfunction is a common comorbidity in patients with chronic pain.
Activation of Liver X receptors (LXRs) plays a potential role in improving cognitive disorders …
Activation of Liver X receptors (LXRs) plays a potential role in improving cognitive disorders …
[HTML][HTML] Irisin alleviates chronic constriction injury-induced hyperalgesia and affective disorders in mice through NF-κB and Nrf2 signaling pathways
X Xie, X Yu, H Zhang, H Dai, Y Huang, F Wu - IBRO Neuroscience Reports, 2024 - Elsevier
This research is to explore the impacts of irisin on hyperalgesia and behavioral deficits
caused by chronic constriction injury (CCI) and the underlying mechanisms. The CCI mice …
caused by chronic constriction injury (CCI) and the underlying mechanisms. The CCI mice …