International AIDS Society global scientific strategy: towards an HIV cure 2016
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …
global population of more than 35 million people living with HIV, there is intense interest in …
Understanding HIV latency: the road to an HIV cure
MS Dahabieh, E Battivelli, E Verdin - Annual review of medicine, 2015 - annualreviews.org
Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the …
individuals. However, treatment has to be continued for life because it does not lead to the …
HIV latency is established directly and early in both resting and activated primary CD4 T cells
L Chavez, V Calvanese, E Verdin - PLoS pathogens, 2015 - journals.plos.org
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …
Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latency
VA Evans, RM Van Der Sluis, A Solomon… - Aids, 2018 - journals.lww.com
Objective: In HIV-infected individuals on antiretroviral therapy (ART), latent HIV is enriched
in CD4+ T cells expressing immune checkpoint molecules, in particular programmed cell …
in CD4+ T cells expressing immune checkpoint molecules, in particular programmed cell …
Immunologic strategies for HIV-1 remission and eradication
DH Barouch, SG Deeks - Science, 2014 - science.org
Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals
who have access to these medications, are able to tolerate these drugs, and are motivated …
who have access to these medications, are able to tolerate these drugs, and are motivated …
Human dendritic cell subsets, ontogeny, and impact on HIV infection
JW Rhodes, O Tong, AN Harman… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) play important roles in orchestrating host immunity against invading
pathogens, representing one of the first responders to infection by mucosal invaders. From …
pathogens, representing one of the first responders to infection by mucosal invaders. From …
Barriers for HIV cure: the latent reservoir
S Castro-Gonzalez, M Colomer-Lluch… - AIDS research and …, 2018 - liebertpub.com
Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …
The multifaceted nature of HIV latency
C Dufour, P Gantner, R Fromentin… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …
How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?
J Ananworanich, K Dubé… - Current Opinion in HIV and …, 2015 - journals.lww.com
It is clear that early ART has a greater impact in limiting the HIV reservoirs than later
treatment. However, latently infected long-lived memory CD4+ T cells persist in most early …
treatment. However, latently infected long-lived memory CD4+ T cells persist in most early …