In recent years, industry has reduced its investment in US biomedical research and
development by billions of dollars, while increasing investment in Asia–Oceania. Thus …

Background To demonstrate that subject selection based on sufficient laboratory results and
medication orders in electronic health records can be biased towards sick patients. Methods …

Drug-induced toxicity damages the health and is one of the key factors causing drug
withdrawal from the market. It is of great significance to identify drug-induced target-organ …

In the face of drastically rising drug discovery costs, strategies promising to reduce
development timelines and expenditures are being pursued. Computer-aided virtual …

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Cancer is a serious problem affecting the health of all human societies. Chemotherapy
refers to the use of drugs to kill cancer or the origin of cancer. In the past three decades …

We present a longitudinal analysis of investigational new drug applications (INDs) for new,
systemic antibacterial drugs under active development between 1980 and 2019, evaluating …

The integration of artificial intelligence (AI) into an evidence-based modern drug discovery
platform will likely result in revolutionary advancement. Although modern medicine remains …

The late-stage introduction of allyl groups provides an opportunity to synthetic organic
chemists for subsequent diversification, furnishing a rapid access to new chemical space …

Translational neuroscience is in the doldrums. The stroke research community was among
the first to recognize that the motivations inherent in our system of research can cause …