The evaluation of absorption, distribution, metabolism, exclusion, and toxicity (ADMET)
properties plays a key role in a variety of domains including industrial chemicals …

Rising health care costs are a major problem in the United States. Over the last ten years,
increases in health care costs have driven down real income gains for individuals and …

Drug discovery and toxicology is a complex process that involves considerable basic
research and preclinical evaluation. These depend highly on animal testing which often fails …

Highlights•Early hazard identification, reliable risk assessment and diligent risk avoidance
strategies are essential.•We describe why toxicology should be an integrated discipline …

Osteoarthritis (OA) is the most prevalent arthritis with an estimated global prevalence in
2020 of 22.9%(95% confidence interval [CI], 19.8%-26.1%) in persons over 40 years of age …

Direct-acting antivirals (DAAs) have dramatically changed the landscape of hepatitis C
treatment and prevention. The World Health Organization has called for the elimination of …

Abstract The B. 1.617. 2 Delta variant is considered to be the most infectious of all SARS-
CoV2 variants. Here, an attempt has been made through in-silico screening of 55 bioactive …

In a clinical trial, people with the same disease can show different responses after treatment
with the same drug and exactly under the same conditions. Some of them may improve …

CNS disorders are indications with a very high unmet medical needs, relatively smaller
number of available drugs, and a subpar satisfaction level among patients and caregiver …

Identifying drug-target interactions is crucial for drug discovery. Despite modern
technologies used in drug screening, experimental identification of drug-target interactions …