In the current investigation, we have compared the potential of statin drugs (Simvastatin,
Rosuvastatin and Fluvastatin) as potential anti-bacterial agent by conducting in silico, in vitro …

Leishmaniasis is a group of zoonotic diseases caused by a trypanosomatid parasite mostly
in impoverished populations of low-income countries. In their different forms, leishmaniasis …

Despite extensive breakthroughs in chemistry, molecular biology, and genetics in the last
decades, the success rates of drug development projects remain low. To improve …

Public health budgets and individual patients around the world struggle with high prices for
pharmaceutical products. Difficulties are not limited to lowincome countries. Prices for newly …

Idiosyncratic drug‐induced liver injury (IDILI) is a significant source of drug recall and acute
liver failure (ALF) in the United States. While current drug development processes …

Drugs for ultra-rare disorders (URDs) rank prominently among the most expensive
medicines on a cost-per-patient basis. Many of them do not meet conventional standards for …

Gastrointestinal (GI) cancers comprise a significant number of cancer cases worldwide and
contribute to a high percentage of cancer-related deaths. To improve survival rates of GI …

The lack of advanced animal models of human cancers is considered a barrier to
developing effective therapeutics. Canine and human melanomas are histologically …

Highlights•Study of impeding factors leading to system failure in drug development.•
Overview of solution directions to repair current drug development system.•Importance of …

There is an urgent unmet need for novel antifungals. In this study, we searched for novel
antifungal activities in the Pandemic Response Box, a collection of 400 structurally diverse …