[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

M Zoulikha, Q Xiao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …

Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation

GF Nieman, LA Gatto, P Andrews, J Satalin… - Annals of intensive …, 2020 - Springer
Mortality in acute respiratory distress syndrome (ARDS) remains unacceptably high at
approximately 39%. One of the only treatments is supportive: mechanical ventilation …

Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China

J Xu, X Yang, L Yang, X Zou, Y Wang, Y Wu, T Zhou… - Critical Care, 2020 - Springer
Background The global numbers of confirmed cases and deceased critically ill patients with
COVID-19 are increasing. However, the clinical course, and the 60-day mortality and its …

Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study

Y Yu, D Xu, S Fu, J Zhang, X Yang, L Xu, J Xu, Y Wu… - Critical care, 2020 - Springer
Background A COVID-19 outbreak started in Wuhan, China, last December and now has
become a global pandemic. The clinical information in caring of critically ill patients with …

[HTML][HTML] Mesenchymal stem cell–derived extracellular vesicles alleviate acute lung injury via transfer of miR-27a-3p

J Wang, R Huang, Q Xu, G Zheng, G Qiu… - Critical Care …, 2020 - journals.lww.com
Objectives: The goal of this study was to determine the role of microRNA transfer in
mediating the effects of mesenchymal stem cell–derived extracellular vesicles in acute lung …

Epidemiology of neonatal acute respiratory distress syndrome: prospective, multicenter, international cohort study

D De Luca, DG Tingay, AH Van Kaam… - Pediatric Critical Care …, 2022 - journals.lww.com
OBJECTIVES: Age-specific definitions for acute respiratory distress syndrome (ARDS) are
available, including a specific definition for neonates (the “Montreux definition”). The …

Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation

D Wang, X Chai, CG Magnussen, GR Zosky… - Pulmonary …, 2019 - Elsevier
While effective treatments for acute respiratory distress syndrome (ARDS) are lacking,
mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with …

[HTML][HTML] Cell therapy in acute respiratory distress syndrome

S Horie, HE Gonzalez, JG Laffey… - Journal of thoracic …, 2018 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) is driven by a severe pro-inflammatory
response resulting in lung damage, impaired gas exchange and severe respiratory failure …

A physiologically informed strategy to effectively open, stabilize, and protect the acutely injured lung

GF Nieman, H Al-Khalisy, M Kollisch-Singule… - Frontiers in …, 2020 - frontiersin.org
Acute respiratory distress syndrome (ARDS) causes a heterogeneous lung injury and
remains a serious medical problem, with one of the only treatments being supportive care in …

Future trends in nebulized therapies for pulmonary disease

SD McCarthy, HE González, BD Higgins - Journal of Personalized …, 2020 - mdpi.com
Aerosol therapy is a key modality for drug delivery to the lungs of respiratory disease
patients. Aerosol therapy improves therapeutic effects by directly targeting diseased lung …