Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications

R Mohammadpour, MA Dobrovolskaia… - Advanced drug delivery …, 2019 - Elsevier
Inorganic nanoparticles provide the opportunity to localize bioactive agents to the target
sites and protect them from degradation. In many cases, acute toxicities of inorganic …

Recent advances in the redox-responsive drug delivery nanoplatforms: A chemical structure and physical property perspective

S Mollazadeh, M Mackiewicz… - Materials Science and …, 2021 - Elsevier
Poor water solubility, off-target toxicity, and small therapeutic window are among major
obstacles for the development of drug products. Redox-responsive drug delivery …

Engineered hybrid nanoparticles for on-demand diagnostics and therapeutics

KT Nguyen, Y Zhao - Accounts of chemical research, 2015 - ACS Publications
Conspectus Together with the simultaneous development of nanomaterials and molecular
biology, the bionano interface brings about various applications of hybrid nanoparticles in …

Mesoporous silica nanoparticles as cutting-edge theranostics: Advancement from merely a carrier to tailor-made smart delivery platform

P Kumar, P Tambe, KM Paknikar, V Gajbhiye - Journal of Controlled …, 2018 - Elsevier
Large surface area, uniform and tunable pore size, high pore volume and low mass density-
such attractive features of Mesoporous silica nanoparticles (MSNPs) have compelled …

A drug-self-gated and tumor microenvironment-responsive mesoporous silica vehicle:“four-in-one” versatile nanomedicine for targeted multidrug-resistant cancer …

W Cheng, C Liang, X Wang, H Tsai, G Liu, Y Peng… - Nanoscale, 2017 - pubs.rsc.org
The design of multifunctional nanocarriers for the co-delivery of anticancer drugs and
genetic agents offers an effective and promising strategy to combat multidrug-resistant …

Redox-responsive theranostic nanoplatforms based on inorganic nanomaterials

L Han, XY Zhang, YL Wang, X Li, XH Yang… - Journal of Controlled …, 2017 - Elsevier
Spurred on by advances in materials chemistry and nanotechnology, scientists have
developed many novel nanopreparations for cancer diagnosis and therapy. To treat …

Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation …

Y Wu, L Ding, C Zheng, H Li, M Wu, Y Sun, X Liu… - Acta Biomaterialia, 2022 - Elsevier
Photodynamic therapy (PDT) is a promising cancer treatment modality with advantages of
minimal invasiveness, repeatable therapy, and mild systemic toxicity. However, the limited …

Stimuli-responsive biodegradable silica nanoparticles: From native structure designs to biological applications

Q Qi, Q Shen, J Geng, W An, Q Wu, N Wang… - Advances in Colloid and …, 2024 - Elsevier
Due to their inherent advantages, silica nanoparticles (SiNPs) have greatly potential
applications as bioactive materials in biosensors/biomedicine. However, the long-term and …

Versatility of peptide nucleic acids (PNA s): Role in chemical biology, drug discovery, and origins of life

C Sharma, SK Awasthi - Chemical biology & drug design, 2017 - Wiley Online Library
This review briefly discussed nomenclature, synthesis, chemistry, and biophysical properties
of a plethora of PNA derivatives reported since the discovery of aeg PNA. Different synthetic …

Recent advances in multifunctional silica-based hybrid nanocarriers for bioimaging and cancer therapy

WQ Lim, SZF Phua, HV Xu, S Sreejith, Y Zhao - Nanoscale, 2016 - pubs.rsc.org
In recent years, there has been a considerable research focus on integrating cancer cell
imaging and therapeutic functions into single nanoscale platforms for better treatment of …