Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from
the outer surface to the inner compartments of the cell. Long considered as a passive means …

Cytokinesis relies on membrane trafficking pathways regulated by Rabs and guanine
nucleotide exchange factors (GEFs). During cytokinesis, the intercellular cytokinetic bridge …

Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid
communication between cells and their environment. Evidence is now emerging that …

Abstract Small extracellular vesicles (sEVs), 50–150 nm in diameter, have been proposed to
mediate cell–cell communication with important implications in tumor microenvironment …

Thyroid carcinoma (TC) can be classified as medullary (MTC) and non-medullary (NMTC).
While most TCs are sporadic, familial forms of MTC and NMTC also exist (less than 1% and …

Introduction Osteosarcoma is the most common primary malignant tumor in children and
young patients. Although neoadjuvant chemotherapy and surgery could improve the …

Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions
including regulation of endocytosis, vesicle transport, and activation of various signal …

Gastric cancer (GC) is still a major lethal gastrointestinal tumor. In this study, we clarified that
RAB13, which is a member of Rab GTPase family and responsible for cargos delivery …

Mammalian cells utilize Akt‐dependent signaling to deploy intracellular Glut4 toward cell
surface to facilitate glucose uptake. Low‐density lipoprotein receptor (LDLR) is the cargo …