This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

The two major interfaces separating brain and blood have different primary roles. The
choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid …

Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target
of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels …

Autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by
social communication deficits and stereotyped behaviors, may be associated with changes …

The serine/threonine kinase mTORC1 regulates cellular homeostasis in response to many
cues, such as nutrient status and energy level. Amino acids induce mTORC1 activation on …

Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised
of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have …

Glutamine together with glucose is essential for body's homeostasis. It is the most abundant
amino acid and is involved in many biosynthetic, regulatory and energy production …

Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and
are major determinants of cellular metabolism. Several SLCs have been shown to be …

Transporters of the SLC38 family are found in all cell types of the body. They mediate Na+-
dependent net uptake and efflux of small neutral amino acids. As a result they are …

Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient
supplies. This review considers recent advances in our understanding of the AA-sensing …