Perspectives on the development and future of oocyte IVM in clinical practice

M De Vos, M Grynberg, TM Ho, Y Yuan… - Journal of Assisted …, 2021 - Springer
Oocyte in vitro maturation (IVM) is an assisted reproductive technology designed to obtain
mature oocytes following culture of immature cumulus–oocyte complexes collected from …

[HTML][HTML] Future potential of in vitro maturation including fertility preservation

J Cadenas, L la Cour Poulsen, LS Mamsen… - Fertility and …, 2023 - Elsevier
In several mammalian species, oocytes from small antral follicles after in vitro maturation
(IVM) are successfully used for procreation. Humans are the exception, mainly because of …

Intrafollicular concentrations of the oocyte-secreted factors GDF9 and BMP15 vary inversely in polycystic ovaries

SG Kristensen, A Kumar, LS Mamsen… - The Journal of …, 2022 - academic.oup.com
Context The oocyte-secreted factors growth differentiation factor 9 (GDF9) and bone
morphogenetic protein 15 (BMP15) play essential roles in follicle development and oocyte …

Polymorphism Detection of GDF9 Gene and Its Association with Litter Size in Luzhong Mutton Sheep (Ovis aries)

F Wang, M Chu, L Pan, X Wang, X He, R Zhang, L Tao… - Animals, 2021 - mdpi.com
Simple Summary GDF9 and BMPR1B are two important reproduction genes. In this study,
the whole coding region of GDF9 was sequenced, of which the mutations were detected in …

In vitro maturation without gonadotropins versus in vitro fertilization with hyperstimulation in women with polycystic ovary syndrome: a non-inferiority randomized …

X Zheng, W Guo, L Zeng, D Zheng, S Yang… - Human …, 2022 - academic.oup.com
STUDY QUESTION Does in vitro maturation (IVM) result in non-inferior cumulative live birth
rates compared to those after standard in vitro fertilization (IVF) in infertile women with …

Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM

J Cadenas, SE Pors, A Kumar, B Kalra… - Reproductive Biology …, 2022 - Springer
Background The suggested effects of the oocyte secreted GDF9 and BMP15 growth factors
on oocyte maturation are currently based on recombinant proteins, and little is known about …

Phycocyanin improves reproductive ability in obese female mice by restoring ovary and oocyte quality

X Wen, Z Han, SJ Liu, X Hao, XJ Zhang… - Frontiers in Cell and …, 2020 - frontiersin.org
Reproductive dysfunction associated with obesity is increasing among women of
childbearing age. Emerging evidence indicates that maternal obesity impairs embryo …

Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM

N Akin, D Richani, X Liao, Y Zhao, AC Herta… - Journal of Assisted …, 2022 - Springer
Purpose In vitro maturation (IVM) is a technology that generates mature oocytes following
culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by …

[HTML][HTML] Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency-a systematic …

AM Faizal, MH Elias, NM Jin, MA Abu… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
The leading indicator for successful outcomes in in-vitro fertilization (IVF) is the quality of
gametes in oocytes and sperm. Thus, advanced research aims to highlight the parameter in …

A rare germline BMP15 missense mutation causes hereditary ovarian immature teratoma in human

Y Liu, H Fan, X Kang, Y Hao, N Wang… - Proceedings of the …, 2024 - National Acad Sciences
Ovarian immature teratomas (OITs) are malignant tumors originating from the ovarian germ
cells that mainly occur during the first 30 y of a female's life. Early age of onset strongly …