[HTML][HTML] Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch

C Anene, AM Graham, J Boyne, W Roberts - Biochimica et Biophysica Acta …, 2018 - Elsevier
Platelet microparticle (PMP)-induced angiogenesis plays a key role in tumour metastasis
and has been proposed to contribute towards cardiovascular disease by enhancing …

Gold nanoparticles in cardiovascular imaging

M Varna, HV Xuan, E Fort - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Although originally applied in the field of oncology, recent results have illustrated the
considerable potential of gold nanoparticles (GNPs) in the imaging of cardiovascular …

Targeted therapy of atherosclerosis by pH-sensitive hyaluronic acid nanoparticles co-delivering all-trans retinal and rapamycin

N Cheraga, Z Ye, MJ Xu, L Zou, NC Sun, Y Hang… - Nanoscale, 2022 - pubs.rsc.org
Atherosclerosis, the leading cause of death in the elderly worldwide, is typically
characterized by elevated reactive oxygen species (ROS) levels and a chronic inflammatory …

Role of KCa3. 1 channels in macrophage polarization and its relevance in atherosclerotic plaque instability

R Xu, C Li, Y Wu, L Shen, J Ma, J Qian… - … , and Vascular Biology, 2017 - Am Heart Assoc
Objective—Emerging evidence indicates that proinflammatory macrophage polarization
imbalance plays a key role in atherosclerotic plaque progression and instability. The calcium …

Markers of atherosclerosis: part 2–genetic and imaging markers

M Tibaut, M Caprnda, P Kubatka, A Sinkovič… - Heart, lung and …, 2019 - Elsevier
This is Part 2 of a two-part review summarising current knowledge on biomarkers of
atherosclerosis. Part 1 addressed serological biomarkers. Here, in part 2 we address …

[HTML][HTML] Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE-/-mice with minimal side effects

L Zhang, C Wang, W Hu, T Bu, W Sun, T Zhou, S Qiu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Senescent cells in plaques emerge as a detrimental factor for atherosclerosis (AS), for which
targeted senolysis might be a promising therapeutic strategy. The development of safe and …

Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through …

ME Reschen, KJ Gaulton, D Lin, EJ Soilleux… - PLoS …, 2015 - journals.plos.org
Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of
coronary artery disease (CAD) and the causal mechanisms at the majority of loci are …

Myeloperoxidase: a potential therapeutic target for coronary artery disease

T Chaikijurajai, WHW Tang - Expert opinion on therapeutic targets, 2020 - Taylor & Francis
Introduction Coronary artery disease (CAD) poses significant morbidity and mortality
globally. Despite significant advances in treatment interventions, residual cardiovascular …

Attenuated superoxide dismutase 2 activity induces atherosclerotic plaque instability during aging in hyperlipidemic mice

AE Vendrov, MD Stevenson, S Alahari… - Journal of the …, 2017 - Am Heart Assoc
Background Atherosclerosis progression during aging culminates in the development of
vulnerable plaques, which may increase the risk of cardiovascular events. Increased …

[HTML][HTML] Macrophages: First guards in the prevention of cardiovascular diseases

MI Nasser, S Zhu, H Huang, M Zhao, B Wang, H Ping… - Life sciences, 2020 - Elsevier
Cardiovascular diseases (CVD) remain one of the leading causes of mortality worldwide,
especially in developing countries. It is widely known that severe inflammation can lead to …