Caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury is mediated via RhoA and ROCK activation in major pelvic ganglion

JL Hannan, H Matsui, NA Sopko, X Liu, E Weyne… - Scientific reports, 2016 - nature.com
Axonal injury due to prostatectomy leads to Wallerian degeneration of the cavernous nerve
(CN) and erectile dysfunction (ED). Return of potency is dependent on axonal regeneration …

European Society for Sexual Medicine consensus statement on the use of the cavernous nerve injury rodent model to study postradical prostatectomy erectile …

E Weyne, MM Ilg, OO Cakir, A Muneer… - Sexual …, 2020 - academic.oup.com
Introduction Rodent animal models are currently the most used in vivo model in translational
studies looking into the pathophysiology of erectile dysfunction after nerve-sparing radical …

Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve …

I Kovanecz, S Rivera, G Nolazco… - The journal of sexual …, 2012 - academic.oup.com
Introduction Long-term daily administration of phosphodiesterase type 5 (PDE5) inhibitors in
the rat prevents or reverses corporal veno-occlusive dysfunction (CVOD) and smooth …

Drug delivery options and therapeutic advances in the management of erectile dysfunction

PT Grice, J Liu, AT Gabrielson, I Pearce… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Erectile dysfunction (ED) is defined as the inability to achieve or maintain an
erection sufficient for satisfactory sexual performance. It is estimated that 20–30% of adult …

Emerging tools for erectile dysfunction: a role for regenerative medicine

L Hakim, F Van der Aa, TJ Bivalacqua… - Nature Reviews …, 2012 - nature.com
Erectile dysfunction (ED) is the most common sexual disorder reported by men to their
health-care providers and the most investigated male sexual dysfunction. Currently, the …

Nanotechnology-assisted adipose-derived stem cell (ADSC) therapy for erectile dysfunction of cavernous nerve injury: in vivo: cell tracking, optimized injection dosage …

H Wu, WH Tang, LM Zhao, DF Liu… - Asian journal of …, 2018 - journals.lww.com
Stem cell therapy is a potentially promising option for erectile dysfunction; however, its risk of
tumorigenicity is a clinical hurdle and the risk is positively related to the number of injected …

Stem-cell therapy for erectile dysfunction

R Yiou - Bio-medical materials and engineering, 2017 - content.iospress.com
Stem cell-based therapies have been recently investigated in the field of organic erectile
dysfunctions, such as those associated with diabetes or the treatment of prostate cancer …

Beneficial effect of PEDF-transfected ADSCs on erectile dysfunction in a streptozotocin-diabetic rat model

J Lu, Z Xin, Q Zhang, D Cui, Y Xiao, J Zhuo, F Sun… - Cell and tissue …, 2016 - Springer
Diabetes mellitus (DM) is an important risk factor for erectile dysfunction. Adipose-derived
stem cells (ADSCs) are essential for maintaining erectile function but their function is …

Intratunical injection of stromal vascular fraction prevents fibrosis in a rat model of Peyronie's disease

F Castiglione, P Hedlund, E Weyne, L Hakim… - BJU …, 2019 - Wiley Online Library
Objective To investigate whether local injection of autologous adipose stromal vascular
fraction (SVF) can prevent the development of fibrosis and elastosis in the tunica albuginea …

Regeneration of sensory but not motor axons following visceral nerve injury

SC Payne, PJ Belleville, JR Keast - Experimental neurology, 2015 - Elsevier
Following peripheral nerve injury, restoration of function may occur via the regeneration of
injured axons or compensatory sprouting of spared axons. Injury to visceral nerves that …