Metabotropic glutamate (mGlu) receptors, a family of G-protein-coupled receptors, have
been identified as novel therapeutic targets based on extensive research supporting their …

Drug addiction is a chronic and relapsing brain disorder characterized by compulsive drug
seeking and continued drug use despite adverse consequences. The high prevalence and …

The role of glutamate system in the etiology and pathophysiology of psychiatric disorders
has gained considerable attention in the past two decades, including dysregulation of the …

Abstract Purpose of Review Disruptions in glutamate hemostasis have been implicated in
cocaine use disorder (CUD). This manuscript reviews novel agents that influence glutamate …

It is well established that glutamate plays an important role in drug-induced and cue-induced
reinstatement of drug seeking. However, the role of glutamate in drug reward is unclear. In …

Background and Purpose It has been well established that glutamate in the nucleus
accumbens (NAc) plays a critical role in the motivation to take drugs of abuse. We have …

Abstract Psychostimulant Use Disorder (PUD) is a chronic relapsing disorder with high
motivation for drug abuse. In addition to developing PUD, the use of psychostimulants is a …

Decrease of glutamate transporter-1 (GLT-1) in the spinal dorsal horn after nerve injury
induces enhanced excitatory transmission and causes persistent pain. Histone deacetylases …

Rationale After a history of intermittent cocaine intake, rats develop patterns of drug use
characteristic of substance use disorder. The dorsal striatum is involved in the increased …

Introduction: Major depressive disorder (MDD) and cocaine use disorder (CUD) are
prevalent and frequently co-occur. When co-occurring, the presence of one disorder typically …