HIV-1 drug resistance and resistance testing
DS Clutter, MR Jordan, S Bertagnolio… - Infection, Genetics and …, 2016 - Elsevier
The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …
HIV: cell binding and entry
The first step of the human immunodeficiency virus (HIV) replication cycle—binding and
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …
Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial
JP Casazza, EM Cale, S Narpala, GV Yamshchikov… - Nature medicine, 2022 - nature.com
Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti-
HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …
HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …
Structure of a V3-containing HIV-1 gp120 core
C Huang, M Tang, MY Zhang, S Majeed, E Montabana… - Science, 2005 - science.org
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant
and contains features essential for coreceptor binding. We determined the structure of V3 in …
and contains features essential for coreceptor binding. We determined the structure of V3 in …
Research article (new england journal of medicine) severe anemia in malawian children
JCJ Calis, KS Phiri, EB Faragher, BJ Brabin… - Malawi Medical …, 2016 - ajol.info
Background: Severe anemia is a major cause of sickness and death in African children, yet
the causes of anemia in this population have been inadequately studied. Methods: We …
the causes of anemia in this population have been inadequately studied. Methods: We …
[HTML][HTML] Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives
L Pawig, C Klasen, C Weber, J Bernhagen… - Frontiers in …, 2015 - frontiersin.org
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
Genotypic resistance testing of HIV-1 DNA in peripheral blood mononuclear cells
C Chu, D Armenia, C Walworth… - Clinical Microbiology …, 2022 - Am Soc Microbiol
SUMMARY HIV-1 DNA exists in nonintegrated linear and circular episomal forms and as
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …
GP120: target for neutralizing HIV-1 antibodies
R Pantophlet, DR Burton - Annu. Rev. Immunol., 2006 - annualreviews.org
The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate
the surface of HIV-1 and a major target for neutralizing antibodies. However, immunization …
the surface of HIV-1 and a major target for neutralizing antibodies. However, immunization …
[HTML][HTML] The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
GB Karlsson Hedestam, RAM Fouchier… - Nature Reviews …, 2008 - nature.com
The ability to elicit broadly neutralizing antibody responses against HIV-1 is a crucial goal for
a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 …
a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 …
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1
entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the …
entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the …