Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in
the development process of new drug products. This article provides an overview on some …

The purposes of the review are to: a) Provide a comprehensible introduction of the-state-
ofthe-art sciences of solubility and dissolution, b) introduce typical technologies to assess …

Lipid based drug delivery systems, and in particular self-emulsifying drug delivery systems
(SEDDS), show great potential for enhancing oral bioavailability but have not been broadly …

Literature data are reviewed regarding the scientific advisability of allowing a waiver of in
vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage …

The rate and extent of drug dissolution in the gastrointestinal (GI) tract are highly dependent
upon drug physicochemical properties and GI fluid properties. Biorelevant dissolution media …

Summary and Conclusions Depending on the dose size and solubility characteristics of low
solubility drugs, a meaningful and discriminatory power of dissolution rate testing can be …

The acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes
respiratory failure. Despite numerous clinical trials, there are no molecularly targeted …

Vegetable oils are commonly used as components in many cosmetic products intended for
daily care due to their high beneficial and multifunctional effect on skin. The general …

In this study the significant effect of chitosan on improving the dissolution rate and
bioavailability of aceclofenac has been demonstrated by simple solvent change method …

Particle size reduction can be used for enhancing the dissolution of poorly water-soluble
drugs in order to enhance bioavailability. In nanosuspensions, the particle size of the drug is …