Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica

Y Ma, N Liu, P Greisen, J Li, K Qiao, S Huang… - Nature …, 2022 - nature.com
Substrate inhibition of enzymes can be a major obstacle to the production of valuable
chemicals in engineered microorganisms. Here, we show substrate inhibition of lycopene …

The history, state of the art and future prospects for oleaginous yeast research

F Abeln, CJ Chuck - Microbial cell factories, 2021 - Springer
Lipid-based biofuels, such as biodiesel and hydroprocessed esters, are a central part of the
global initiative to reduce the environmental impact of the transport sector. The vast majority …

Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica

Y Ma, J Li, S Huang, G Stephanopoulos - Metabolic Engineering, 2021 - Elsevier
Metabolic engineering approaches for the production of high-value chemicals in
microorganisms mostly use the cytosol as general reaction vessel. However, sequestration …

Physiological limitations and opportunities in microbial metabolic engineering

J Montaño López, L Duran, JL Avalos - Nature Reviews Microbiology, 2022 - nature.com
Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …

Yarrowia lipolytica Strains and Their Biotechnological Applications: How Natural Biodiversity and Metabolic Engineering Could Contribute to Cell Factories …

C Madzak - Journal of Fungi, 2021 - mdpi.com
Among non-conventional yeasts of industrial interest, the dimorphic oleaginous yeast
Yarrowia lipolytica appears as one of the most attractive for a large range of white …

Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications

J Lian, S Mishra, H Zhao - Metabolic engineering, 2018 - Elsevier
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …

Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica–a review

J Wang, R Ledesma-Amaro, Y Wei, B Ji, XJ Ji - Bioresource Technology, 2020 - Elsevier
Current energy security and climate change policies encourage the development and
utilization of bioenergy. Oleaginous yeasts provide a particularly attractive platform for the …