Mechanosensitive channels (MSCs) play an important role in how cells transduce
mechanical stimuli into electrical or chemical signals, which provides an interventional …

Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels
widely expressed throughout the central and peripheral nervous systems. They are involved …

Abundant ion-channels, including various perceptual receptors, chloride channels,
purinergic receptor channels, and water channels that exist on the ocular surface, play an …

The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels,
provide cholinergic signaling, and are modulated by various venom toxins and drugs in …

Acid‐sensing ion channels (ASICs) are important players in detecting extracellular
acidification throughout the brain and body. ASICs have large extracellular domains …

FMRFamide (Phe-Met-Arg-Phe-amide, FMRFa) and similar neuropeptides are important
physiological modulators in most invertebrates, but the molecular basis of FMRFa activity at …

Acid-sensing ion channels (ASICs) are proton-gated ion channels that mediate nociception
in the peripheral nervous system and contribute to fear and learning in the central nervous …

As one of the key injury incidents, tissue acidosis in the brain occurs very quickly within
several minutes upon the onset of ischemic stroke. Glutamate, an excitatory amino acid …

Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-d-
aspartate receptor)-dependent cell death pathways in stroke,, but unsuccessful clinical trials …