Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Cancer cells evolve in the tumor microenvironment (TME) by the acquisition of
characteristics that allow them to initiate their passage through a series of events that …

Liver injury causes vascular disorganization and local tissue hypoxia starting early in
disease course. In this context, hypoxia acts not only as an aggravating factor of cell damage …

Oxygen is both an environmental and developmental signal that governs important cellular
pathways. Therefore, hypoxia (or low oxygen tensions) is part of both physiological and …

Hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and
radioresistance of hepatocellular carcinoma (HCC); suppresses differentiation and …

Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of
advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib …

Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in
solid tumors. Under hypoxia conditions, HIF-1α protein is stabilized and forms a heterodimer …

Increased expression of Hypoxia-inducible factor-1α (HIF-1α) in the tumor
microenvironment, mainly due to tumor growth, plays a major role in the growth of cancer …

Background Despite well-studied tumor hypoxia in laboratory, little is known about the
association with other pathophysiological events in the clinical view. We investigated the …