Post-translational modifications and subcellular localizations modulate transcription factors,
generating a code that is deciphered into an activity. We describe our current understanding …

The tumor microenvironment (TME) is characterized by an acidic pH and low oxygen
concentrations. Hypoxia induces neoplastic cell evasion of the immune surveillance, rapid …

We studied the role of hypoxia-inducible factor-1α (HIF-1α) in human lung adenocarcinoma
cell invasion using a metastatic cell model composed of low invasive CL1 and highly …

Tumor‐initiating cells (TICs) existing in breast cancer are thought to be involved in initiation,
progression, and relapse of tumors. In these processes, the epithelial‐to‐mesenchymal …

Objectives. To further understand the expression regulation of MMP-1 and MMP-13 under
physiological and pathological conditions, we investigated the combined effects of hypoxia …

The prognosis of patients with hepatocellular carcinoma (HCC) may be improved by novel
treatments focusing on the characteristic metabolic changes of this disease. Therefore, we …

Abstract Background and Objectives The aim of this study was to examine the potential
associations of two hypoxia inducible factor‐1α (HIF‐1α) gene polymorphisms, C1772T and …

Epidermal wound repair is a complex process involving the fine orchestrated regulation of
crucial cell functions, such as proliferation, adhesion and migration. Using an in vitro model …

The SCF/c-kit signaling plays an important role in invasion of c-kit-expressing tumor cells,
however, the molecular mechanisms have not been studied yet. Using a pancreatic cancer …

Tissue hypoxia contributes to solid tumor pathogenesis by activating a series of adaptive
programs. We previously showed that hypoxia promotes the preferential expansion and …