The persistence of drug taking despite its adverse consequences plays a central role in the
presentation, diagnosis, and impacts of addiction. Eventual recognition and appraisal of …

Neuronal ensembles are local, sparsely distributed populations of neurons that are reliably
re-activated by a specific stimulus, context or task. Such discrete cell populations can be …

How does binge drinking alcohol change synaptic function, and do these changes maintain
binge consumption? The anterior insular cortex (AIC) and dorsolateral striatum (DLS) are …

Many fundamental questions on alcohol use disorder (AUD) are frequently difficult to
address by examining a single brain structure, but should be viewed from the whole brain …

Excessive use of alcohol promotes the development of alcohol addiction, but the
understanding of how alcohol-induced brain alterations lead to addiction remains limited. To …

Background Alcohol acts as an addictive substance that may lead to alcohol use disorder. In
humans, magnetic resonance imaging showed diverse structural and functional brain …

Human neuroimaging has demonstrated the existence of large-scale functional networks in
the cerebral cortex consisting of topographically distant brain regions with functionally …

Rationale Alcohol use is reliably preceded by discrete and contextual stimuli which, through
diverse learning processes, acquire the capacity to promote alcohol use and relapse to …

Background Intermittent access to ethanol drives persistent escalation of intake and rapid
transition from moderate to compulsive‐like drinking. Intermittent ethanol drinking may …

Chronic pain and alcohol use disorder (AUD) are highly comorbid, and patients with chronic
pain are more likely to meet the criteria for AUD. Evidence suggests that both conditions …