Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at
DNA lesions, which is catalyzed by poly (ADP-ribose) polymerases (PARPs). This …

Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

Despite the frequent use of ionising radiation (IR) in therapy and diagnostics and the
unavoidable exposure to external radiation sources, our knowledge regarding the …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Radiation therapy plays an important role in the management of a wide range of cancers.
Besides innovations in the physical application of radiation dose, radiation therapy is likely …

A defining characteristic of damage induced in the DNA by ionizing radiation (IR) is its
clustered character that leads to the formation of complex lesions challenging the cellular …

Although the DNA double-strand break (DSB) is defined as a rupture in the double-stranded
DNA molecule that can occur without chemical modification in any of the constituent building …

More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …