Neuroprotective effects of agri-food by-products rich in phenolic compounds

A Rojas-García, Á Fernández-Ochoa, ML Cádiz-Gurrea… - Nutrients, 2023 - mdpi.com
Neurodegenerative diseases are known for their wide range of harmful conditions related to
progressive cell damage, nervous system connections and neuronal death. These …

Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

HM Al-Kuraishy, MS Jabir, AI Al-Gareeb… - Ageing Research …, 2023 - Elsevier
In Alzheimer disease (AD), amyloid precursor protein (APP) and production of amyloid beta
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …

Therapeutic potential of ADAM10 modulation in Alzheimer's disease: a review of the current evidence

MR Khezri, M Mohebalizadeh… - Cell Communication and …, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common neurodegenerative disease
worldwide, is caused by loss of neurons and synapses in central nervous system. Several …

Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action

P Bellavite - Antioxidants, 2023 - mdpi.com
Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

[HTML][HTML] p-Coumaric acid mitigates passive avoidance memory and hippocampal synaptic plasticity impairments in aluminum chloride-induced Alzheimer's disease rat …

M Rashno, P Gholipour, I Salehi, A Komaki… - Journal of Functional …, 2022 - Elsevier
The present study was designed to determine the effects of p-coumaric acid (p-CA), a
phenolic compound, on passive avoidance memory function and hippocampal long-term …

The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome

AA Mahmoud, AM Elfiky, FS Abo-Zeid - Steroids, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is a multi-factorial endocrine disorder associated with
hyperandrogenism. Dehydroepiandrosterone (DHEA) administration to prepubertal rats …

Paradigms and Success Stories of Natural Products in Drug Discovery Against Neurodegenerative Disorders (NDDs)

S Singh, S Chib, MJ Akhtar, B Kumar… - Current …, 2024 - ingentaconnect.com
Neurodegenerative disorders (NDDs) are multifaceted complex disorders that have put a
great health and economic burden around the globe nowadays. The multi-factorial nature of …

Characterization of orange peel extract and its potential protective effect against aluminum chloride-induced Alzheimer's disease

NM Abd El-Aziz, MG Shehata, T Alsulami, AN Badr… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure.
Hence, developing an effective treatment or protective agent is crucial for public health. The …

A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease

X Wu, X Zheng, H Tang, L Zhao, C He, Y Zou, X Song… - Medicine, 2022 - journals.lww.com
Background: Alzheimer disease (AD) is a degenerative brain disease, which may lead to
severe memory loss and other cognitive disorders. However, few effective drugs are …

A diet containing rutin ameliorates brain intracellular redox homeostasis in a mouse model of Alzheimer's disease

P Bermejo-Bescós, KL Jiménez-Aliaga… - International Journal of …, 2023 - mdpi.com
Quercetin has been studied extensively for its anti-Alzheimer's disease (AD) and anti-aging
effects. Our previous studies have found that quercetin and in its glycoside form, rutin, can …