Highlights•Structure-based strategies allow more-specific targeting of protein–protein
interactions (PPIs).•Interfering peptides (IPs) become a promising alternative to small …

Highly accurate protein structure predictions by deep neural networks such as AlphaFold2
and RoseTTAFold have tremendous impact on structural biology and beyond. Here, we …

Peptides possess several attractive features when compared to small molecule and protein
therapeutics, such as high structural compatibility with target proteins, the ability to disrupt …

A wide range of regulatory processes in the cell are mediated by flexible peptides that fold
upon binding to globular proteins. Computational efforts to model these interactions are …

Flexible peptides that fold upon binding to another protein molecule mediate a large number
of regulatory interactions in the living cell and may provide highly specific recognition …

Peptide-protein interactions contribute a significant fraction of the protein-protein
interactome. Accurate modeling of these interactions is challenging due to the vast …

Molecular glues are a class of small molecules that stabilize the interactions between
proteins. Naturally occurring molecular glues are present in many areas of biology where …

Since the reformulation of the amyloid cascade hypothesis to focus on oligomeric
aggregates of amyloid beta as the prime toxic species causing Alzheimer's disease, many …

Peptide-protein interactions are ubiquitous in the cell and form an important part of the
interactome. Computational docking methods can complement experimental …

Protein–peptide interactions play a crucial role in a variety of cellular processes. The protein–
peptide complex structure is a key to understand the mechanisms underlying protein …