Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways

T Jin, Y Zhang, BOA Botchway, J Zhang, R Fan… - Food and Chemical …, 2022 - Elsevier
Parkinson's disease is a common progressive neurodegenerative disease, and presently
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …

Aluminum neurotoxicity and autophagy: a mechanistic view

S Makhdoomi, S Ariafar, F Mirzaei… - Neurological …, 2023 - Taylor & Francis
It is strongly believed that aluminum is one of the insalubrious agents because of its
neurotoxicity effects and influences on amyloid β (Aβ) production and tau protein …

Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress …

MO Yıldız, H Çelik, C Caglayan, FM Kandemir, C Gür… - Neurotoxicology, 2022 - Elsevier
Fluoride is an element with toxic properties and has been proven to have some adverse
effects on many soft tissues, including brain tissue. This study aims to evaluate the protective …

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia …

L Calderón-Garcidueñas, A González-Maciel… - Environmental …, 2020 - Elsevier
Fine particulate air pollution (PM 2.5) exposures are linked with Alzheimer's and Parkinson's
diseases (AD, PD). AD and PD neuropathological hallmarks are documented in children …

[HTML][HTML] Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway

W Hao, X Zhu, Z Liu, Y Song, S Wu, X Lu, J Yang… - Ecotoxicology and …, 2023 - Elsevier
Purpose Aluminum is an environmental toxicant whose long-term exposure is closely
associated with nervous system impairment. This study mainly investigated neurological …

Exploring the combined effect of exercise and apigenin on aluminium-induced neurotoxicity in zebrafish

S Boopathi, E Mendonca, A Gandhi, A Rady… - Molecular …, 2024 - Springer
Aluminium (AL) is a strong environmental neurotoxin linked to neurodegenerative disorders.
Widespread industrial use leads to its presence in water systems, causing bioaccumulation …

[HTML][HTML] Zebrafish: A pharmacological model for learning and memory research

JK Tan, FH Nazar, S Makpol, SL Teoh - Molecules, 2022 - mdpi.com
Learning and memory are essential to organism survival and are conserved across various
species, especially vertebrates. Cognitive studies involving learning and memory require …

Nicotinamide: oversight of metabolic dysfunction through sirt1, mtor, and clock genes

K Maiese - Current neurovascular research, 2020 - ingentaconnect.com
Metabolic disorders that include diabetes mellitus present significant challenges for
maintaining the welfare of the global population. Metabolic diseases impact all systems of …

[HTML][HTML] Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al

C He, X Zhao, Y Lei, J Nie, X Lu, J Song, L Wang… - … therapy-nucleic acids, 2021 - cell.com
Aluminum is a known neurotoxin that can induce Aβ deposition and abnormal
phosphorylation of tau protein, leading to Alzheimer disease (AD)-like damages such as …

Necrostatin-1 relieves learning and memory deficits in a zebrafish model of Alzheimer's disease induced by aluminum

X Gao, P Zhang, J Chen, L Zhang, N Shang… - Neurotoxicity …, 2022 - Springer
Aluminum (Al) is considered one of the environmental risk factors for Alzheimer's disease
(AD). The present study aims to establish a zebrafish AD model induced by Al and explore if …