Dendritic cells (DCs) are the dominant class of antigen-presenting cells in humans and are
largely responsible for the initiation and guidance of innate and adaptive immune responses …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …

Islet gene expression has been widely studied to better understand the transcriptional
features that define a healthy β-cell. Transcriptomes of FACS-purified α-, β-, and δ-cells …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …

In vitro models of the pancreas can aid in developing therapies for pancreatic diseases.
Nonetheless, most pancreatic tissue engineering is limited to insulin‐secreting β‐cells or …

A variety of studies indicate that microRNAs (miRNAs) are involved in diabetes. However,
the direct role of miR-320a in the pathophysiology of pancreatic β cells under diabetes …

The possibility of using human embryonic stem (hES) cell-derived β cells as an alternative to
cadaveric islets for the treatment of type 1 diabetes is now widely acknowledged. However …

Graft vascularization is a crucial step to obtain stable normoglycemia in pancreatic islet
transplantation. Endothelial progenitor cells (EPCs) contribute to neoangiogenesis and to …

The islets of Langerhans is the endocrine function region of pancreas, which exist in five cell
types. The majority of endocrine cells are insulin-secreting β cells, mixed up with glucagon …

Over the past few years, extensive efforts have been made to generate in-vitro pancreatic
micro-tissue, for disease modeling or cell replacement approaches in pancreatic related …