The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of
cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water …

Gynecologic cancer is a group of any malignancies affecting reproductive tissues and
organs of women, including ovaries, uterine, cervix, vagina, vulva, and endometrium …

Exosomes are small extracellular membrane vesicles of endocytic origin released by many
cells that could be found in most body fluids. The main functions of exosomes are cellular …

Despite a growing interest in development of non-cytotoxic targeted agents, systemic
chemotherapy is still the mainstay of treatment for both non-small cell lung cancer (NSCLC) …

A number of chemotherapeutic agents, such as platinum drugs, nitrogen mustards, and
chloroethylnitrosoureas, act by forming bifunctional DNA adducts. It is likely that abortive …

Platinum (Pt)-based antitumor agents are effective in the treatment of many solid
malignancies. However, their efficacy is limited by toxicity and drug resistance. Reduced …

Purpose Platinum agents cause DNA cross-linking and oxidative damage. Genetic
polymorphisms of DNA repair genes are associated with differential DNA repair activity and …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Purpose: Nucleotide excision repair (NER) modulates platinum-based chemotherapeutic
efficacy by removing drug-produced DNA damage. To summarize published data on the …

Background: Non-small-cell lung cancer (NSCLC) is frequently resistant to chemotherapy,
and this resistance has been associated with elevated nucleotide excision repair (NER) in …