Complex cellular responses to reactive oxygen species

MD Temple, GG Perrone, IW Dawes - Trends in cell biology, 2005 - cell.com
Genome-wide analyses of yeast provide insight into cellular responses to reactive oxygen
species (ROS). Many deletion mutants are sensitive to at least one ROS, but no one oxidant …

De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial …

JF Nijkamp, M van den Broek, E Datema, S de Kok… - Microbial cell …, 2012 - Springer
Abstract Saccharomyces cerevisiae CEN. PK 113-7D is widely used for metabolic
engineering and systems biology research in industry and academia. We sequenced …

Stress adaptation in a pathogenic fungus

AJP Brown, S Budge, D Kaloriti… - Journal of …, 2014 - journals.biologists.com
Candida albicans is a major fungal pathogen of humans. This yeast is carried by many
individuals as a harmless commensal, but when immune defences are perturbed it causes …

A dynamic model of proteome changes reveals new roles for transcript alteration in yeast

MV Lee, SE Topper, SL Hubler, J Hose… - Molecular systems …, 2011 - embopress.org
The transcriptome and proteome change dynamically as cells respond to environmental
stress; however, prior proteomic studies reported poor correlation between mRNA and …

Role of the Hog1 Stress-activated Protein Kinase in the Global Transcriptional Response to Stress in the Fungal Pathogen Candida albicans

B Enjalbert, DA Smith, MJ Cornell, I Alam… - Molecular biology of …, 2006 - Am Soc Cell Biol
The resistance of Candida albicans to many stresses is dependent on the stress-activated
protein kinase (SAPK) Hog1. Hence we have explored the role of Hog1 in the regulation of …

Condensation of Ded1p promotes a translational switch from housekeeping to stress protein production

C Iserman, CD Altamirano, C Jegers, U Friedrich… - Cell, 2020 - cell.com
Cells sense elevated temperatures and mount an adaptive heat shock response that
involves changes in gene expression, but the underlying mechanisms, particularly on the …

Genome-wide analysis of the biology of stress responses through heat shock transcription factor

JS Hahn, Z Hu, DJ Thiele, VR Iyer - Molecular and cellular biology, 2004 - Taylor & Francis
Heat shock transcription factor (HSF) and the promoter heat shock element (HSE) are
among the most highly conserved transcriptional regulatory elements in nature. HSF …

High-resolution DNA-binding specificity analysis of yeast transcription factors

C Zhu, KJRP Byers, RP McCord, Z Shi… - Genome …, 2009 - genome.cshlp.org
Transcription factors (TFs) regulate the expression of genes through sequence-specific
interactions with DNA-binding sites. However, despite recent progress in identifying in vivo …

Exploring the conditional coregulation of yeast gene expression through fuzzy k-means clustering

AP Gasch, MB Eisen - Genome biology, 2002 - Springer
Background Organisms simplify the orchestration of gene expression by coregulating genes
whose products function together in the cell. Many proteins serve different roles depending …

The enigma of environmental pH sensing in plants

HH Tsai, W Schmidt - Nature Plants, 2021 - nature.com
Environmental pH is a critical parameter for innumerable chemical reactions, myriad
biological processes and all forms of life. The mechanisms that underlie the perception of …