Many fungi grow over a wide pH range and their gene expression is tailored to the
environmental pH. In Aspergillus nidulans, the transcription factor PacC, an activator of …

SUMMARY TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase
that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and …

Yeast cells modulate their protein synthesis capacity in response to physiological needs
through the transcriptional control of ribosomal protein (RP) genes. Here we demonstrate …

All cells undergo rapid transcriptional reprogramming in response to environmental changes
by mobilizing transcriptional activators and repressors. Transcriptional activator proteins …

Uncovering the mechanisms underlying robust responses of cells to stress is crucial for our
understanding of cellular physiology. Indeed, vast amounts of data have been collected on …

Yeast cells respond to stress by mediating condition-specific gene expression changes and
by mounting a common response to many stresses, called the environmental stress …

In Saccharomyces cerevisiae, the Ca 2+/calmodulin-dependent protein phosphatase,
calcineurin, is activated by specific environmental conditions, including exposure to Ca 2+ …

The preferred source of carbon and energy for yeast cells is glucose. When yeast cells are
grown in liquid cultures, they metabolize glucose predominantly by glycolysis, releasing …

The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being
revealed as a central signaling mediator during osmoregulation in the budding yeast …

Several computational methods based on microarray data are currently used to study
genome-wide transcriptional regulation. Few studies, however, address the combinatorial …