The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …

The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin
(mTOR) signaling pathways are two pathways crucial to many aspects of cell growth and …

Localized radiotherapy (RT) induces an immunogenic antitumor response that is in part
counterbalanced by activation of immune evasive and tissue remodeling processes, eg, via …

The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It
is now appreciated that angiogenesis is also essential for the dissemination and …

Abstract c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however,
emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK …

Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-
cancer strategy that in order to be realized must overcome several obstacles, including …

In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more and more
attention for their potential biomedical applications. With their tailored mesoporous structure …

CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

Peptides cancer vaccines are designed based on the epitope peptides that can elicit
humoral and cellular immune responses targeting tumor‐associated antigens (TAAs) or …

Introduction The vascular endothelial growth factor A (VEGF) is the main mediator of
angiogenesis. In addition, VEGF contributes to cancer growth and metastasis directly …