OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt–NF-κB and MAPK signaling pathways
Since the introduction of angiogenesis as a useful target for cancer therapy, few agents have
been approved for clinical use due to the rapid development of resistance. This problem can …
been approved for clinical use due to the rapid development of resistance. This problem can …
Associations of microRNAs, angiogenesis-regulating factors and CFH Y402H polymorphism—An attempt to search for systemic biomarkers in age-related macular …
Z Ulańczyk, A Sobuś, K Łuczkowska… - International journal of …, 2019 - mdpi.com
Age-related macular degeneration (AMD) remains the leading cause of blindness in elderly
people, but the pathophysiology of this disease is still largely unknown. We investigated the …
people, but the pathophysiology of this disease is still largely unknown. We investigated the …
68Ga-DOTA-NGR as a novel molecular probe for APN-positive tumor imaging using MicroPET
J Zhang, X Lu, N Wan, Z Hua, Z Wang, H Huang… - Nuclear medicine and …, 2014 - Elsevier
Aminopeptidase N (APN) is selectively expressed on many tumors and the endothelium of
tumor neovasculature, and may serve as a promising target for cancer diagnosis and …
tumor neovasculature, and may serve as a promising target for cancer diagnosis and …
Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
Anti-angiogenic therapies have generated significant interest for their potential to combat
tumor growth. However, tumor overproduction of pro-angiogenic ligands can overcome …
tumor growth. However, tumor overproduction of pro-angiogenic ligands can overcome …
Targeting angiogenesis with peptide vaccines
MA Rahat - Frontiers in Immunology, 2019 - frontiersin.org
Most cancer peptide vaccinations tested so far are capable of eliciting a strong immune
response, but demonstrate poor clinical benefits. Since peptide vaccination is safe and well …
response, but demonstrate poor clinical benefits. Since peptide vaccination is safe and well …
Punarnavine, an alkaloid from Boerhaavia diffusa exhibits anti-angiogenic activity via downregulation of VEGF in vitro and in vivo
S Saraswati, AA Alhaider, SS Agrawal - Chemico-Biological Interactions, 2013 - Elsevier
Punarnavine, a quinolizidine alkaloid isolated from Boerhaavia diffusa is known to possess
analgesic, anti-inflammatory, hepato-protective, immunomodulatory and anti-proliferative …
analgesic, anti-inflammatory, hepato-protective, immunomodulatory and anti-proliferative …
[HTML][HTML] Optimization of early response monitoring and prediction of cancer antiangiogenesis therapy via noninvasive PET molecular imaging strategies of …
X Bao, MW Wang, JM Luo, SY Wang, YP Zhang… - Theranostics, 2016 - ncbi.nlm.nih.gov
Objective: Antiangiogenesis therapy (AAT) has provided substantial benefits regarding
improved outcomes and survival for suitable patients in clinical settings. Therefore, the early …
improved outcomes and survival for suitable patients in clinical settings. Therefore, the early …
Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology
LC Gomes-da-Silva, S Simões, JN Moreira - Cellular and molecular life …, 2014 - Springer
The identification of numerous deregulated signaling pathways on cancer cells and
supportive stromal cells has revealed several molecular targets whose downregulation can …
supportive stromal cells has revealed several molecular targets whose downregulation can …
Amelioration of Dalton's lymphoma–induced angiogenesis by melatonin
R Kumari, K Rawat, A Kumari… - Tumor Biology, 2017 - journals.sagepub.com
For tumor to grow beyond 1–2 mm3 size, tumor recruits new blood vessels referred as
angiogenesis; therefore, targeting angiogenesis can be a promising strategy to suppress …
angiogenesis; therefore, targeting angiogenesis can be a promising strategy to suppress …
[HTML][HTML] NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway
N Yoshinaga, N Arimura, H Otsuka, K Kawahara… - Laboratory …, 2011 - Elsevier
Intraocular neovascularization is the leading cause of severe visual loss and anti-vascular
endothelial growth factor (VEGF) therapy is currently performed for choroidal …
endothelial growth factor (VEGF) therapy is currently performed for choroidal …